More than 400 workers - mostly in London - are expected to lose their jobs as Barclays Bank announced a review of its operations.
The jobs, in its IT departments, are principally in Cheshire and London, the bank announced.
It said it would try to avoid compulsory redundancies by releasing contractors and closing vacancies.
The union Unite described the job cuts as a "serious loss", especially in the current economic uncertainty.
Barclays said in a statement: "As part of the review process, we have identified some aspects of our technology operations where the organisational structure impedes performance, and roles and responsibilities for colleagues are unclear.

source: bbc